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EXPOL profile for Gene FYN

Gene Description FYN oncogene related to SRC, FGR, YES

Chromosomal Location Chromosome Chr:6q21
Genomic Region: UCSC Golden Path for FYN ;    Ensembl Link for FYN

Localization Molecular Localization: ---
Subcellular Localization: ---

Gene Ontology Information Biological Process: 6468 // protein amino acid phosphorylation // traceable author statement /// 6816 // calcium ion transport // non-traceable author statement /// 7242 // intracellular signaling cascade // inferred from electronic annotation /// 7243 // protein kinase cascade // traceable author statement /// 7612 // learning // traceable author statement /// 7631 // feeding behavior // traceable author statement /// 8151 // cell growth and/or maintenance // inferred from electronic annotation
Cellular Component: ---
Molecular Function: 4713 // protein-tyrosine kinase activity // traceable author statement /// 4715 // non-membrane spanning protein tyrosine kinase activity // non-traceable author statement /// 5524 // ATP binding // non-traceable author statement /// 16740 // transferase activity // inferred from electronic annotation

Pathway Information Integrin-mediated_cell_adhesion
KEGG

Protein Information InterPro: IPR008266 // Tyrosine protein kinase, active site /// IPR000719 // Protein kinase /// IPR000980 // SH2 motif /// IPR001452 // SH3 /// IPR002290 // Serine/threonine protein kinase /// IPR001245 // Tyrosine protein kinase
SCOP: scop // d1dcqa2 // d1dcqa2 SCOP:g.45.1.1:| Pyk2-associated protein beta ARF-GAP domain // --- /// scop // d1fmk_1 // d1fmk_1 SCOP:b.34.2.1:| c-src protein tyrosine kinase // --- /// scop // d1fmk_3 // d1fmk_3 SCOP:d.144.1.7:| c-src tyrosine kinase // --- /// scop // d1g83a2 // d1g83a2 SCOP:d.93.1.1:| Tyrosine kinase Fyn // ---
Swissprot: BAC85751 /// P06241 /// Q16248 /// Q8N5D7
Pfam: pkinase // Protein kinase domain;3.5e-80 /// pkinase // Protein kinase domain;3.2e-66 /// SH3 // SH3 domain;4.7e-29 /// pkinase // Protein kinase domain;6.9e-80 /// SH2 // SH2 domain;8e-43
Blocks: IPB000959 // POLO box duplicated region;0.0046
Protein Families: ec // ZA70_HUMAN // ZA70_HUMAN EC:2.7.1.112:TYROSINE-PROTEIN KINASE ZAP-70 (EC 2.7.1.112) (70 KDA ZETA-ASSOCIATED PROTEIN) (SYK-RELATED TYROSINE KINASE). // --- /// Hanks // FYN // FYN_HUMAN (FYN) KINASES:4.1.3 | PTK GROUP A - Non Membrane spanning protein tyrosine kinases.PTK I Src family .FYN // ---

Unigene Information UnigeneID: Hs.390567
Tissue Expression

Other links for Gene: FYN Locus Link ID: 2534 GDB Link for FYN   NCBI Link for FYN ;   Gene Card for FYN

Expression in Blood

Mean Expression( No. of Arrays)
Coefficient of Variation
Expression call in Blood(EST)

2.66 (9) Expression Graph
0.06 Weakly expressed

Unrelated Age Matched Females Differential Gene Expression
Show Data

Twins Differential Gene Expression
NOT FOUND AS DIFFERENTIALLY EXPRESSED

Simple Repeats (TG/CA)_n

Category

Type I

Type II

Type III

ALU Repeats

No. of ALU Repeats
Gene Region occupied by ALU (Length in bp, %)
% GC of Gene
Gene Length

37 Alu Y
10093,  4.76 42.46 212143

Gene Description	FYN oncogene related to SRC, FGR, YES
Chromosomal Location	Chromosome Chr:6q21 Genomic Region: UCSC Golden Path for FYN ; Ensembl Link for FYN
Localization	Molecular Localization: --- Subcellular Localization: ---
Gene Ontology Information	Biological Process: 6468 // protein amino acid phosphorylation // traceable author statement /// 6816 // calcium ion transport // non-traceable author statement /// 7242 // intracellular signaling cascade // inferred from electronic annotation /// 7243 // protein kinase cascade // traceable author statement /// 7612 // learning // traceable author statement /// 7631 // feeding behavior // traceable author statement /// 8151 // cell growth and/or maintenance // inferred from electronic annotation Cellular Component: --- Molecular Function: 4713 // protein-tyrosine kinase activity // traceable author statement /// 4715 // non-membrane spanning protein tyrosine kinase activity // non-traceable author statement /// 5524 // ATP binding // non-traceable author statement /// 16740 // transferase activity // inferred from electronic annotation
Pathway Information	Integrin-mediated_cell_adhesion KEGG
Protein Information	InterPro: IPR008266 // Tyrosine protein kinase, active site /// IPR000719 // Protein kinase /// IPR000980 // SH2 motif /// IPR001452 // SH3 /// IPR002290 // Serine/threonine protein kinase /// IPR001245 // Tyrosine protein kinase SCOP: scop // d1dcqa2 // d1dcqa2 SCOP:g.45.1.1:\| Pyk2-associated protein beta ARF-GAP domain // --- /// scop // d1fmk_1 // d1fmk_1 SCOP:b.34.2.1:\| c-src protein tyrosine kinase // --- /// scop // d1fmk_3 // d1fmk_3 SCOP:d.144.1.7:\| c-src tyrosine kinase // --- /// scop // d1g83a2 // d1g83a2 SCOP:d.93.1.1:\| Tyrosine kinase Fyn // --- Swissprot: BAC85751 /// P06241 /// Q16248 /// Q8N5D7 Pfam: pkinase // Protein kinase domain;3.5e-80 /// pkinase // Protein kinase domain;3.2e-66 /// SH3 // SH3 domain;4.7e-29 /// pkinase // Protein kinase domain;6.9e-80 /// SH2 // SH2 domain;8e-43 Blocks: IPB000959 // POLO box duplicated region;0.0046 Protein Families: ec // ZA70_HUMAN // ZA70_HUMAN EC:2.7.1.112:TYROSINE-PROTEIN KINASE ZAP-70 (EC 2.7.1.112) (70 KDA ZETA-ASSOCIATED PROTEIN) (SYK-RELATED TYROSINE KINASE). // --- /// Hanks // FYN // FYN_HUMAN (FYN) KINASES:4.1.3 \| PTK GROUP A - Non Membrane spanning protein tyrosine kinases.PTK I Src family .FYN // ---
Unigene Information	UnigeneID: Hs.390567 Tissue Expression
Other links for Gene: *FYN*	Locus Link ID: 2534 GDB Link for FYN NCBI Link for FYN ; Gene Card for FYN