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Institute of Genomics and Integrative Biology

EXPOL profile for Gene FYN

Gene Description FYN oncogene related to SRC, FGR, YES

Chromosomal Location Chromosome Chr:6q21
Genomic Region: UCSC Golden Path for FYN ;    Ensembl Link for FYN

Localization Molecular Localization: ---
Subcellular Localization: ---

Gene Ontology Information Biological Process: 6468 // protein amino acid phosphorylation // traceable author statement /// 6816 // calcium ion transport // non-traceable author statement /// 7242 // intracellular signaling cascade // inferred from electronic annotation /// 7243 // protein kinase cascade // traceable author statement /// 7612 // learning // traceable author statement /// 7631 // feeding behavior // traceable author statement /// 8151 // cell growth and/or maintenance // inferred from electronic annotation
Cellular Component: ---
Molecular Function: 4713 // protein-tyrosine kinase activity // traceable author statement /// 4715 // non-membrane spanning protein tyrosine kinase activity // non-traceable author statement /// 5524 // ATP binding // non-traceable author statement /// 16740 // transferase activity // inferred from electronic annotation

Pathway Information Integrin-mediated_cell_adhesion

Protein Information InterPro: IPR008266 // Tyrosine protein kinase, active site /// IPR000719 // Protein kinase /// IPR000980 // SH2 motif /// IPR001452 // SH3 /// IPR002290 // Serine/threonine protein kinase /// IPR001245 // Tyrosine protein kinase
SCOP: scop // d1dcqa2 // d1dcqa2 SCOP:g.45.1.1:| Pyk2-associated protein beta ARF-GAP domain // --- /// scop // d1fmk_1 // d1fmk_1 SCOP:b.34.2.1:| c-src protein tyrosine kinase // --- /// scop // d1fmk_3 // d1fmk_3 SCOP:d.144.1.7:| c-src tyrosine kinase // --- /// scop // d1g83a2 // d1g83a2 SCOP:d.93.1.1:| Tyrosine kinase Fyn // ---
Swissprot: BAC85751 /// P06241 /// Q16248 /// Q8N5D7
Pfam: pkinase // Protein kinase domain;3.5e-80 /// pkinase // Protein kinase domain;3.2e-66 /// SH3 // SH3 domain;4.7e-29 /// pkinase // Protein kinase domain;6.9e-80 /// SH2 // SH2 domain;8e-43
Blocks: IPB000959 // POLO box duplicated region;0.0046
Protein Families: ec // ZA70_HUMAN // ZA70_HUMAN EC:2.7.1.112:TYROSINE-PROTEIN KINASE ZAP-70 (EC 2.7.1.112) (70 KDA ZETA-ASSOCIATED PROTEIN) (SYK-RELATED TYROSINE KINASE). // --- /// Hanks // FYN // FYN_HUMAN (FYN) KINASES:4.1.3 | PTK GROUP A - Non Membrane spanning protein tyrosine kinases.PTK I Src family .FYN // ---

Unigene Information UnigeneID: Hs.390567

Other links for Gene: FYN Entrez GeneID: 2534 GDB Link for FYN
NCBI Link for FYN ; GeneCard Link for FYN

Expression in Blood

Mean Expression( No. of Arrays)
Coefficient of Variation
Expression call in Blood(EST)

2.66 (9)
0.06 Weakly expressed

Differential Gene Expression

Unrelated Age Matched Female Individuals

Pair 1
Pair 2
Pair 3
Pair 4
Pair 5
Pair 6
Pair 7
Pair 8
Pair 9

2.2
4.4
3.2
2.8
5
1.7
1.9
3.4
5.6

Monozygotic Twins

NOT FOUND AS DIFFERENTIALLY EXPRESSED

Simple Repeats (TG/CA)_n

Category

Polymorphic Repeats

Location
Genbank ID
Marker ID
Heterozygosity
Alleles

INTRON9 D6S302 Z17016 0.61 9

Other Simple Repeats

Select /Enter repeat to be searched : Dinucleotide Repeat
Other Microsatellite Repeat

      Cut-Off :

ALU Repeats

No. of ALU Repeats
Gene Region occupied by ALU (Length in bp, %)
% GC of Gene
Gene Length

37
10093,  4.76 42.46 212143

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©2006 IGIB

Gene Description	FYN oncogene related to SRC, FGR, YES
Chromosomal Location	Chromosome Chr:6q21 Genomic Region: UCSC Golden Path for *FYN* ; Ensembl Link for *FYN*
Localization	Molecular Localization: --- Subcellular Localization: ---
Gene Ontology Information	Biological Process: 6468 // protein amino acid phosphorylation // traceable author statement /// 6816 // calcium ion transport // non-traceable author statement /// 7242 // intracellular signaling cascade // inferred from electronic annotation /// 7243 // protein kinase cascade // traceable author statement /// 7612 // learning // traceable author statement /// 7631 // feeding behavior // traceable author statement /// 8151 // cell growth and/or maintenance // inferred from electronic annotation Cellular Component: --- Molecular Function: 4713 // protein-tyrosine kinase activity // traceable author statement /// 4715 // non-membrane spanning protein tyrosine kinase activity // non-traceable author statement /// 5524 // ATP binding // non-traceable author statement /// 16740 // transferase activity // inferred from electronic annotation
Pathway Information	Integrin-mediated_cell_adhesion
Protein Information	InterPro: IPR008266 // Tyrosine protein kinase, active site /// IPR000719 // Protein kinase /// IPR000980 // SH2 motif /// IPR001452 // SH3 /// IPR002290 // Serine/threonine protein kinase /// IPR001245 // Tyrosine protein kinase SCOP: scop // d1dcqa2 // d1dcqa2 SCOP:g.45.1.1:\| Pyk2-associated protein beta ARF-GAP domain // --- /// scop // d1fmk_1 // d1fmk_1 SCOP:b.34.2.1:\| c-src protein tyrosine kinase // --- /// scop // d1fmk_3 // d1fmk_3 SCOP:d.144.1.7:\| c-src tyrosine kinase // --- /// scop // d1g83a2 // d1g83a2 SCOP:d.93.1.1:\| Tyrosine kinase Fyn // --- Swissprot: BAC85751 /// P06241 /// Q16248 /// Q8N5D7 Pfam: pkinase // Protein kinase domain;3.5e-80 /// pkinase // Protein kinase domain;3.2e-66 /// SH3 // SH3 domain;4.7e-29 /// pkinase // Protein kinase domain;6.9e-80 /// SH2 // SH2 domain;8e-43 Blocks: IPB000959 // POLO box duplicated region;0.0046 Protein Families: ec // ZA70_HUMAN // ZA70_HUMAN EC:2.7.1.112:TYROSINE-PROTEIN KINASE ZAP-70 (EC 2.7.1.112) (70 KDA ZETA-ASSOCIATED PROTEIN) (SYK-RELATED TYROSINE KINASE). // --- /// Hanks // FYN // FYN_HUMAN (FYN) KINASES:4.1.3 \| PTK GROUP A - Non Membrane spanning protein tyrosine kinases.PTK I Src family .FYN // ---
Unigene Information	UnigeneID: Hs.390567
Other links for Gene: *FYN*	Entrez GeneID: 2534 GDB Link for *FYN* NCBI Link for *FYN* ; GeneCard Link for *FYN*

Polymorphic Repeats	Location	Genbank ID	Marker ID	Heterozygosity	Alleles
	INTRON9	D6S302	Z17016	0.61	9